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Symbol
Name
ID 		Ins2
insulin II
MGI:96573
Phenotype annotations related to endocrine/exocrine glands
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Diabetes mellitus
Diabetic ketoacidosis
Maturity-onset diabetes of the young
Type I diabetes mellitus
Type II diabetes mellitus
Exocrine pancreatic insufficiency
Pancreatic adenocarcinoma
Disease(s) Associated with INS
maturity-onset diabetes of the young type 10
pancreatic cancer
permanent neonatal diabetes mellitus
type 1 diabetes mellitus
type 1 diabetes mellitus 2
type 2 diabetes mellitus

Mouse Phenotypes
increased pancreatic islet cell apoptosis
salivary gland inflammation
endocrine/exocrine gland phenotype
abnormal pancreatic islet morphology
abnormal pancreatic alpha cell morphology
increased pancreatic alpha cell number
abnormal pancreatic beta cell morphology
decreased pancreatic beta cell mass
increased pancreatic beta cell mass
decreased pancreatic beta cell number
increased pancreatic beta cell number
degranulated pancreatic beta cells
small pancreatic islets
disorganized pancreatic islets
abnormal Leydig cell morphology
abnormal pancreatic beta cell physiology
decreased insulin secretion
increased insulin secretion
abnormal pancreas physiology
insulitis
Availability Mouse Genotype
Ins1tm1Jja/Ins1tm1Jja
Ins2Akita/Ins2Akita
Ins2tm1Jja/Ins2tm1Jja
Ins2Akita/Ins2+
Ins2C95S/Ins2+
Ins2em#Arak/Ins2+
Tg(H2-Ea-Ins2)1Wehi/0 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory